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GeoVax Labs to launch phase II trials of HIV vaccine candidate

The Atlanta-based biotechnology firm GeoVax Labs plans to launch Phase II clinical trials of its experimental HIV vaccine this summer, company officials recently announced, the Atlanta Journal-Constitution reports (Hendrick, Atlanta Journal-Constitution, 5/8).

8 May 2008

Outcomes of obese and nonobese patients undergoing revision total hip arthroplasty

Along with age and injuries, obesity is a leading risk factor for osteoarthritis (OA), a painful and disabling joint disease. While excessive weight can aggravate the toll on almost any joint, obesity has been associated with a higher prevalence of hip OA and an increase in total hip arthroplasty (THA).

8 May 2008

Study finds darapladib lowers biomarker for cardiovascular problems

Despite widespread use of cholesterol-lowering drugs, a significant number of cardiac patients continue to suffer heart attacks and stroke. Researchers theorize that high levels of an enzyme found in coronary plaques may be to blame, by making plaques more likely to rupture and block blood flow. The drug darapladib may offer a way to fight that risk, according to new research led by the University of Pennsylvania School of Medicine.

8 May 2008

Study finds arthritis can be a barrier for adults seeking to manage diabetes through exercise

More than half of adults with diagnosed diabetes also have arthritis, a painful condition that can be a barrier to physical activity -- an important health strategy for managing diabetes, according to a study released by the Centers for Disease Control and Prevention in today's Morbidity and Mortality Weekly Report.

8 May 2008

Department of Health announces adult autism strategy

This prevalence study will inform the first ever Government strategy on adults with autism and Asperger's syndrome, due to be published next year.

8 May 2008

Lack of motivation in schizophrenia linked to brain chemical imbalance

A study of patients with psychotic illnesses such as schizophrenia suggests an alternative explanation for why many sufferers lack motivation. The research is described in BioMed Central's journal BMC Psychiatry.

8 May 2008

Color Doppler ultrasound should be first imaging technique for diagnosing suspected acute appendicitis

Color Doppler ultrasound, not CT, should be the first imaging examination for adult patients with suspected acute appendicitis, a new study emphasizes.

7 May 2008

Study suggests caution on a new anti-obesity drug in children

A new class of anti-obesity drugs that suppresses appetite by blocking cannabinoid receptors in the brain could also suppress the adaptive rewiring of the brain necessary for neural development in children, studies with mice have indicated.

7 May 2008

Vitamin D linked to reduced mortality rate in chronic kidney disease

For patients with moderate to severe chronic kidney disease (CKD), treatment with activated vitamin D may reduce the risk of death by approximately one-fourth, suggests a study in the August Journal of the American Society of Nephrology.

7 May 2008

Role of genetic components of dendritic cells could lead to more effective drugs

For the first time, researchers from the University of Pittsburgh School of Medicine have identified genetic components of dendritic cells that are key to asthma and allergy-related immune response malfunction. Targeting these elements could result in more effective drugs to treat allergic disorders and asthma, according to a study reported in the May edition of the journal Nature Medicine.

7 May 2008

microRNAs appear essential for retinal health

Retinas in newborn mice appear perfectly fine without any help from tiny bits of genetic material called microRNAs except for one thing - the retinas do not work.

7 May 2008

New study shows how sounds are amplified in the inner ear

St. Jude Children's Research Hospital investigators have found that an electrically powered amplification mechanism in the cochlea of the ear is critical to the acute hearing of humans and other mammals. The findings will enable better understanding of how hearing loss can result from malfunction of this amplification machinery due to genetic mutation or overdose of drugs such as aspirin.

7 May 2008

Obesity may increase adults' risk for having dementia

Their analysis of published obesity and dementia prospective follow-up studies over the past two decades shows a consistent relationship between the two diseases. The results are published by The International Association for the Study of Obesity in the May, 2008 issue of Obesity Reviews.

7 May 2008

CardioTech receives approval for a second graft size for CardioPass clinical trial

CardioTech International, Inc., a developer and manufacturer of advanced medical devices and materials for the treatment of a broad range of disease states, today announced that it has received the necessary Ministry of Health approval to add a 4mm graft for the clinical trial of CardioPass , the Company's proprietary synthetic coronary bypass graft. Until now, the trial was only approved for a 5mm graft.

7 May 2008

Major mental disorders cost society billions in unearned income

Major mental disorders cost the nation at least $193 billion annually in lost earnings alone, according to a new study funded by the National Institutes of Health's National Institute of Mental Health (NIMH). The study was published in the May 2008 issue of the American Journal of Psychiatry.

7 May 2008

Obesity can increase dementia risk by up to 80 per cent - people who are underweight also face an elevated risk

Being obese can increase the risk of Alzheimer's Disease by as much as 80 per cent, according to a study in the May issue of the UK-based journal Obesity Reviews.

7 May 2008

Quit smoking and the benefits soon appear

New research says that people who give up smoking begin to improve their health almost immediately, and the risk of death from all causes falls by 13% within 5 years and to no extra risk of death by 20 years.

7 May 2008

Suicide victims who were abused have genetic brain difference

Canadian researchers have found that childhood abuse victims who later commit suicide have marked genetic differences in their brains.

7 May 2008

Fat transplantation can have metabolic benefits

When transplanted deep into the abdomen, fat taken from just under the skin comes with metabolic benefits, or at least it does in mice, reveals a new study in the May issue of Cell Metabolism, a Cell Press publication.

6 May 2008

Corticosteroids not linked with reduced risk of death for children with bacterial meningitis

Use of corticosteroids in addition to other treatment for children with bacterial meningitis is not associated with a decreased risk of death or shorter hospital stay, according to a study in the May 7 issue of JAMA, the Journal of the American Medical Association.

6 May 2008

Drug Trial News

GeoVax Labs to launch phase II trials of HIV vaccine candidate

Outcomes of obese and nonobese patients undergoing revision total hip arthroplasty

Study finds darapladib lowers biomarker for cardiovascular problems

Study finds arthritis can be a barrier for adults seeking to manage diabetes through exercise

Department of Health announces adult autism strategy

Lack of motivation in schizophrenia linked to brain chemical imbalance

Color Doppler ultrasound should be first imaging technique for diagnosing suspected acute appendicitis

Study suggests caution on a new anti-obesity drug in children

Vitamin D linked to reduced mortality rate in chronic kidney disease

Role of genetic components of dendritic cells could lead to more effective drugs

microRNAs appear essential for retinal health

New study shows how sounds are amplified in the inner ear

Obesity may increase adults' risk for having dementia

CardioTech receives approval for a second graft size for CardioPass clinical trial

Major mental disorders cost society billions in unearned income

Obesity can increase dementia risk by up to 80 per cent - people who are underweight also face an elevated risk

Quit smoking and the benefits soon appear

Suicide victims who were abused have genetic brain difference

Fat transplantation can have metabolic benefits

Corticosteroids not linked with reduced risk of death for children with bacterial meningitis

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