T Cell News and Research

Latest T Cell News and Research

Suramin shows promise as COVID-19 treatment

A new study published on the preprint server bioRxiv reports the elucidation of the mechanism of inhibition of SARS-CoV-2 by a non-nucleotide inhibitor called suramin. This is the first such compound to be shown to have such activity and shows promise for use as a repurposed drug against COVID-19.

12 Oct 2020

Study reveals why immobilization after injury helps in healing

By far, the most common injuries seen in emergency rooms in the United States are those affecting extremities. Immobilization is the most common treatment, and yet, until recently, it was unknown exactly why this technique worked to advance healing.

12 Oct 2020

Integrin b3 and ACE2 linked by short linear motifs enabling endocytosis and autophagy of SARS-CoV-2

A new study by Uppsala University researchers published on the preprint server bioRxiv in October 2020 shows possible links between the angiotensin-converting enzyme 2 (ACE2) host cell receptors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the entry of viral particles into the cell via endocytosis and autophagy.

12 Oct 2020

Enzyme SSH1 impairs the disposal of damaged tau and neurotoxic mitochondria

In a healthy brain, the multistep waste clearance process known as autophagy routinely removes and degrades damaged cell components - including malformed proteins like tau and toxic mitochondria.

12 Oct 2020

Leaking components from broken muscle fibers activate 'satellite' muscle stem cells

While building a muscle damage model in a cultured system, a research collaboration between Kumamoto University and Nagasaki University in Japan has found that components leaking from broken muscle fibers activate "satellite" muscle stem cells.

12 Oct 2020

Stem cells that repair broken bones can also generate arthritic bone spurs

The same stem cells that heal broken bones can also generate arthritic bone spurs called osteophytes, according to a new study in the Annals of the Rheumatic Diseases.

12 Oct 2020

Understanding the production of memory B cells and immune responses

The current COVID-19 climate has made vaccines, antibodies, and immune responses topics of everyday conversation.

12 Oct 2020

Study provides a new depth of resolution to understand single gene disorders

Traditionally, geneticists divide disorders into "simple," where a single gene mutation causes disease, or complex, where mutations in many genes contribute modest amounts. A new study suggests that the truth is somewhere in between.

12 Oct 2020

Dynamic map reveals how cells fight microbes and preserve memory for future infections

Researchers have charted the activity of tens of thousands of genes in mouse immune cells over the course of an infection.

12 Oct 2020

Newly identified coronavirus epitopes induce robust antibody responses

Researchers at the University of Wisconsin-Madison have conducted a study showing that infection with severe acute respiratory syndrome coronavirus 2 (SARS-C0V-2) triggers robust immune responses to epitopes across the full viral proteome.

12 Oct 2020

Study elucidates the role of ERβ in growth of skeletal muscle in female mice

Researchers at Kumamoto University, Japan generated mice lacking the estrogen receptor beta (ERβ) gene, both fiber-specific and muscle stem cell-specific, which resulted in abnormalities in the growth and regeneration of skeletal muscle in female mice.

12 Oct 2020

Computational biology algorithm could help optimize culture conditions required for cell therapy

Cellular therapy is a powerful strategy to produce patient-specific, personalised cells to treat many diseases, including heart disease and neurological disorders.

12 Oct 2020

Scientists develop new type of precise therapeutic vaccine against leukemia

Exploration of new leukemia antigens and construction of appropriate delivery systems using FDA-approved material are important strategies for developing leukemia vaccines for clinic use.

12 Oct 2020

Nasal spray COVID-19 vaccine shows promising results in mice

With promising vaccines comes a new candidate that has shown potent pre-clinical immune responses. The vaccine, developed by scientists at the University of Alabama at Birmingham (UAB), induced a potent T-cell response at the mucus layer of the lungs, including killer CD8+ T-cells, which can recognize and kill virally infected cells.

12 Oct 2020

Study shows how mutations in VAV1 gene may promote T-cell tumors in experimental mice

Life is an exquisite orchestration of growth and change, with checks and balances that fine-tune complex entwined interactions, both intrinsic and external.

12 Oct 2020

Scientists discern molecular mechanisms underlying plant parasitism, cross-species grafting

Using the model Orobanchaceae parasitic plant Phtheirospermum japonicum, scientists from Nagoya University and other research institutes from Japan have discerned the molecular mechanisms underlying plant parasitism and cross-species grafting, pinpointing enzyme β-1,4-glucanase (GH9B3) as an important contributor to both phenomena.

12 Oct 2020

A new therapeutic approach for Epstein-Barr virus-associated tumors

A research team at LKS Faculty of Medicine, The University of Hong Kong (HKUMed) discovered that exosomes derived from Vδ2-T cells (Vδ2-T-Exos) can effectively control Epstein-Barr virus-associated tumours and induce T-cell anti-tumour immunity.

12 Oct 2020

New study may lead to more effective, personalized cancer immunotherapies

Neoantigens, tiny markers that arise from cancer mutations, flag cells as cancerous and could be the key to unlocking a new generation of immunotherapies.

12 Oct 2020

Researchers identify molecular mechanisms of IFN responses in SARS-CoV-2 infection

As of October 2020, SARS-CoV-2 causes an ongoing pandemic, with more than 35 million reported cases and more than 1 million deaths worldwide. One prominent feature that distinguishes COVID-19 from SARS in terms of immune responses is the poor induction of a type I interferon (IFN) response by SARS-CoV-2 compared to SARS-CoV and influenza A virus.

12 Oct 2020

Elevated plasma ACE2 activity persists months after SARS-CoV-2 infection

Recently, researchers from the University of Melbourne and Immune Therapies Group, Burnet Institute, Melbourne, reported that downregulation of cardiac ACE2 is linked to increased plasma ACE2 activity. This study is summarized in a preprint paper published in medRxiv.

11 Oct 2020

T Cell News and Research

Latest T Cell News and Research

Suramin shows promise as COVID-19 treatment

Study reveals why immobilization after injury helps in healing

Integrin b3 and ACE2 linked by short linear motifs enabling endocytosis and autophagy of SARS-CoV-2

Enzyme SSH1 impairs the disposal of damaged tau and neurotoxic mitochondria

Leaking components from broken muscle fibers activate 'satellite' muscle stem cells

Stem cells that repair broken bones can also generate arthritic bone spurs

Understanding the production of memory B cells and immune responses

Study provides a new depth of resolution to understand single gene disorders

Dynamic map reveals how cells fight microbes and preserve memory for future infections

Newly identified coronavirus epitopes induce robust antibody responses

Study elucidates the role of ERβ in growth of skeletal muscle in female mice

Computational biology algorithm could help optimize culture conditions required for cell therapy

Scientists develop new type of precise therapeutic vaccine against leukemia

Nasal spray COVID-19 vaccine shows promising results in mice

Study shows how mutations in VAV1 gene may promote T-cell tumors in experimental mice

Scientists discern molecular mechanisms underlying plant parasitism, cross-species grafting

A new therapeutic approach for Epstein-Barr virus-associated tumors

New study may lead to more effective, personalized cancer immunotherapies

Researchers identify molecular mechanisms of IFN responses in SARS-CoV-2 infection

Elevated plasma ACE2 activity persists months after SARS-CoV-2 infection

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T Cell News and Research

Latest T Cell News and Research

Immunology eBook

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

How GLP‑1 Agonists Are Shaping the Future of Obesity Treatment With Dr Bryony Henderson

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