Gene News and Research

Latest Gene News and Research

Phylogenomic characterization of the first genome sequences of the monkeypox virus outbreak variant

Researchers characterized infections caused by the monkeypox virus (MPXV).

2 Jun 2022

The effects of accessory protein mutations and other non-spike mutations on SARS-CoV-2 pathogenesis

Researchers looked into the role played by the accessory proteins using synthetic genomics assembly technology

2 Jun 2022

New discovery could lead to highly effective ways to treat influenza

It happens every year, especially in winter. A virus saunters into your wide-open respiratory tract, worms its way into lung cells, and, next thing you know, you're lying in bed with a fever, aches, and chills - classic symptoms of influenza, or flu.

1 Jun 2022

Stem cell model could provide insights into biological mechanisms that underlie neuropsychiatric disorders

Researchers from the Icahn School of Medicine at Mount Sinai have applied a novel stem cell model to map disease risk variants in human neurons, which could help provide insights into the biological mechanisms that underlie neuropsychiatric disorders such as autism and schizophrenia.

1 Jun 2022

New study uncovers the impact of genetic mutations on lifelong blood cell production

New research has uncovered how genetic mutations hijack the production of blood cells in different periods of life.

1 Jun 2022

Microgravity culture during spaceflight enhances microbial infection process in 3D intestinal models

Infectious microbes have evolved sophisticated means to invade host cells, outwit the body's defenses and cause disease.

1 Jun 2022

New research may open a window to treating aggressive form of B-cell acute lymphoblastic leukemia

Survival has improved greatly in children with acute lymphocytic leukemia (ALL). But a certain form of ALL that occurs mostly in babies is still very lethal, with a survival rate below 50 percent: B-cell acute lymphoblastic leukemia with rearrangements of the mixed lineage leukemia gene, or MLL B-ALL.

1 Jun 2022

People with food allergies less likely to become infected with SARS-CoV-2, study finds

A National Institutes of Health-funded study has found that people with food allergies are less likely to become infected with SARS-CoV-2, the virus that causes COVID-19, than people without them. In addition, while previous research identified obesity as a risk factor for severe COVID-19, the new study has identified obesity and high body mass index (BMI) as associated with increased risk for SARS-CoV-2 infection.

1 Jun 2022

Gene therapy for degenerative retinal disease has no safety concerns but fails to improve vision loss

A 28-patient phase 1 gene therapy clinical trial for the degenerative retinal disease Leber hereditary optic neuropathy (LHON) found no significant safety concerns; however, treatment failed to improve or slow vision loss, with even the highest dose. LHON affects the optic nerve, which carries visual signals from the light-sensing retina to the brain.

1 Jun 2022

Study shows the SARS-CoV-2 accessory protein ORF7a inhibits HLA-I surface expression levels in human cells

Researchers identified a single viral gene product, the accessory factor ORF7a, facilitating SARS-CoV-2 immune evasion by downregulating the surface expression of MHC class I molecules.

1 Jun 2022

UCI-led study identifies sex-specific circuits of muscle signaling to other tissues

A new University of California, Irvine-led study identifies sex-specific circuits of muscle signaling to other tissues and that the organs and processes muscle impacts are markedly different between males and females.

31 May 2022

Researchers identify molecular characteristics linked to increased likelihood of post-vaccination fatigue

Despite their strong effectiveness against SARS-CoV-2, mRNA-based COVID-19 vaccines are associated with adverse post-vaccination effects, such as fatigue; how can this be avoided? In a new study publishing May 31st in the open-access journal PLOS Biology, Ayesa Syenina of the Duke–NUS Medical School in Singapore and colleagues report that a new analysis of blood samples from people vaccinated for COVID-19 has identified distinct molecular characteristics linked to an increased likelihood of post-vaccination fatigue.

31 May 2022

Aging does not influence liver renewal, research shows

The liver has a unique ability to regenerate after damage. However, it was unknown whether this ability decreases as we age.

31 May 2022

Researchers discover how a workhorse protein keeps protein production on track

Cells produce proteins like little factories. But if they make too much at the wrong times it can lead to diseases like cancer, so they control production with a process called RNA interference (RNAi).

31 May 2022

New class of antibiotics found to be highly effective against drug-resistant tuberculosis

Infection by Mycobacterium tuberculosis kills 1.5 million people worldwide every year. Antibiotics to treat TB exist, but in recent years, multi-drug resistant (MDR), extensively drug-resistant (XDR) and totally drug-resistant (TDR) strains of the bacterium have developed.

31 May 2022

Robust and highly multiplexed assay for identification of SARS-CoV-2 variants

Researchers compared the performance of a highly multiplexed mass spectrometry-based commercial assay to identify SARS-CoV-2 variants.

31 May 2022

Evidence on COVID-19 vaccine effectiveness and duration of protection against Omicron

Researchers reported the vaccine effectiveness and duration of immunity against SARS-CoV-2 Omicron.

31 May 2022

IOB's new scRNA-seq protocol provides a snapshot of the cell transcriptome at unprecedented resolution

Single-cell RNA-sequencing (scRNA-seq) shows which genes are turned on in a cell and what their level of transcription is. This allows in-depth assessment of the biology of individual cells, and detection of changes that may indicate disease.

31 May 2022

Researchers identify a human monoclonal antibody that could broadly neutralize several variants of SARS-CoV-2, SARS-CoV, and other coronaviruses

Researchers identified 10-40, a human monoclonal antibody with potent neutralizing activity against SARS-CoV, SARS-CoV-2, and related sarbecoviruses.

30 May 2022

First-of-its-kind platform generates antitumor immunity and improves responses to checkpoint inhibitors

Researchers at The University of Texas MD Anderson Cancer Center have developed an ultrasound-guided cancer immunotherapy platform that generates systemic antitumor immunity and improves the therapeutic efficacy of immune checkpoint blockade.

30 May 2022

Gene News and Research

Latest Gene News and Research

Phylogenomic characterization of the first genome sequences of the monkeypox virus outbreak variant

The effects of accessory protein mutations and other non-spike mutations on SARS-CoV-2 pathogenesis

New discovery could lead to highly effective ways to treat influenza

Stem cell model could provide insights into biological mechanisms that underlie neuropsychiatric disorders

New study uncovers the impact of genetic mutations on lifelong blood cell production

Microgravity culture during spaceflight enhances microbial infection process in 3D intestinal models

New research may open a window to treating aggressive form of B-cell acute lymphoblastic leukemia

People with food allergies less likely to become infected with SARS-CoV-2, study finds

Gene therapy for degenerative retinal disease has no safety concerns but fails to improve vision loss

Study shows the SARS-CoV-2 accessory protein ORF7a inhibits HLA-I surface expression levels in human cells

UCI-led study identifies sex-specific circuits of muscle signaling to other tissues

Researchers identify molecular characteristics linked to increased likelihood of post-vaccination fatigue

Aging does not influence liver renewal, research shows

Researchers discover how a workhorse protein keeps protein production on track

New class of antibiotics found to be highly effective against drug-resistant tuberculosis

Robust and highly multiplexed assay for identification of SARS-CoV-2 variants

Evidence on COVID-19 vaccine effectiveness and duration of protection against Omicron

IOB's new scRNA-seq protocol provides a snapshot of the cell transcriptome at unprecedented resolution

Researchers identify a human monoclonal antibody that could broadly neutralize several variants of SARS-CoV-2, SARS-CoV, and other coronaviruses

First-of-its-kind platform generates antitumor immunity and improves responses to checkpoint inhibitors

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

PhD researcher at LifeArc

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How GLP‑1 Agonists Are Shaping the Future of Obesity Treatment With Dr Bryony Henderson