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Trimeprazine improves β cell function, slows progression of diabetes

β cells in pancreatic islets are responsible for producing insulin, which is essential to regulate blood glucose homeostasis. In type 1 diabetes, pancreatic β cells are destroyed due to an autoimmune attack, whereas in type 2 diabetes, pancreatic β cells may have deficiencies in secreting insulin or insulin-responding tissues can become insulin resistant.

21 Mar 2016

Cobimetinib with vemurafenib may have added benefit in melanoma with BRAF V600 mutation

Cobimetinib (trade name: Cotellic) has been approved since November 2015 in combination with vemurafenib for the treatment of adults with advanced, i.e. metastatic or unresectable, melanoma with a BRAF V600 mutation.

21 Mar 2016

Penn study calls on physicians to avoid over-prescribing opioids for surgical patients

Physicians are prescribing more opioid painkillers than ever before to patients undergoing common surgeries, according to new research from the department of Anesthesiology and Critical Care at the Perelman School of Medicine at the University of Pennsylvania.

21 Mar 2016

Paracetamol does not meet minimum standard of clinical effectiveness in osteoarthritis patients

In a large-scale analysis of pain-relief medication for osteoarthritis, researchers found that paracetamol does not meet the minimum standard of clinical effectiveness in reducing pain or improving physical function in patients with knee and hip osteoarthritis.

18 Mar 2016

New meta-analysis supports link between intake of omega-3 fatty acids and reduction in MDD

According to the World Health Organization, depression is a major cause of disease burden worldwide, affecting an estimated 350 million people. According to the National Institutes of Mental Health, in 2014, an estimated 15.7 million adults aged 18 or older in the United States had at least one major depressive episode in the past year.

18 Mar 2016

Breckenridge Pharmaceutical announces final FDA approval for Gabapentin Oral Solution

Breckenridge Pharmaceutical, Inc. announces the final approval by the U.S. Food and Drug Administration of the Abbreviated New Drug Application for Gabapentin Oral Solution 250 mg per 5 mL, which is AA rated to Neurontin, a drug marketed by Pfizer.

18 Mar 2016

EPFL scientists develop cutting-edge treatment for Alzheimer's disease

In a cutting-edge treatment for Alzheimer's disease, EPFL scientists have developed an implantable capsule that can turn the patient's immune system against the disease.

18 Mar 2016

Older types of arthritis medicine appear to be dangerous for the heart

Many Danes are prescribed NSAIDs for the treatment of painful conditions, fever and inflammation. But the treatment also comes with side effects, including the risk of ulcers and increased blood pressure.

17 Mar 2016

Researchers find major gap in treatment for AF patients at higher risk for stroke

Nearly half of all atrial fibrillation (AF) patients at the highest risk for stroke are not being prescribed blood thinners by their cardiologists, according to a new study by researchers at University of California, San Diego School of Medicine and University of California, San Francisco.

17 Mar 2016

WSU researcher explores new drugs to treat neurological disorders linked to autophagic dysfunction

Repairing the brain's "house-cleaning function," which could help people with Alzheimer's, Parkinson's, amyotrophic lateral sclerosis (ALS) and 100 other diseases, is the focus of recently funded research at Washington State University.

17 Mar 2016

Study finds disparities in discontinuing diabetes drug rosiglitazone following FDA safety alert

Among older adults with diabetes, certain subgroups--including white patients and those with lower incomes--were slower to discontinue the diabetes drug rosiglitazone after a US Food and Drug Administration safety alert, reports a study in the April issue of Medical Care.

17 Mar 2016

New study reveals why certain cancer drugs not always effective in halting tumor growth

New cancer drugs allow doctors to tailor treatment based on the genetic profile of a patient's tumor. However, these drugs don't work at all in some patients, and they lose their effectiveness in others.

17 Mar 2016

Biomarkers may provide novel approaches to monitoring immunosuppressive therapy in organ transplant patients

Recently discovered biomarkers may provide valuable new approaches to monitoring immunosuppressive drug therapy in organ transplant recipients--with the potential for individualized therapy to reduce organ rejection and minimize side effects, according to a special article in the April issue of Therapeutic Drug Monitoring, official journal of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology.

17 Mar 2016

Hedrin celebrates 10th anniversary with launch of new packaging

Hedrin, the UK’s number 1 head lice brand, is celebrating its 10th birthday with a complete refresh of the packaging, to be available in pharmacies from April.

17 Mar 2016

Johns Hopkins scientists develop antibody to curb lung tumor cell growth, breast cancer metastasis

Johns Hopkins scientists report they have developed an antibody against a specific cellular gateway that suppresses lung tumor cell growth and breast cancer metastasis in transplanted tumor experiments in mice, according to a new study published in the February issue of Nature Communications.

17 Mar 2016

Study: Statin drugs can reduce time to clear tuberculosis infection in mice

In a study using mice, the Johns Hopkins University School of Medicine infectious disease experts have added to evidence that statin drugs — known primarily for their cholesterol-lowering effects — can significantly reduce the time it takes to clear tuberculosis infection.

17 Mar 2016

New treatment reduces cerebral damage in out-of-hospital cardiac arrest patients

Among comatose survivors of out-of-hospital cardiac arrest, treatment with inhaled xenon gas combined with hypothermia, compared with hypothermia alone, results in less white matter damage.

16 Mar 2016

Anti-anxiety drug reduces autistic features in Jacobsen syndrome mice

About half of children born with Jacobsen syndrome, a rare inherited disease, experience social and behavioral issues consistent with autism spectrum disorders. Researchers at University of California, San Diego School of Medicine and collaborators developed a mouse model of the disease that also exhibits autism-like social behaviors and used it to unravel the molecular mechanism that connects the genetic defects inherited in Jacobsen syndrome to effects on brain function.

16 Mar 2016

Many kidney transplant patients may benefit from lower-than-standard dose of CNIs

The kidney is the most commonly transplanted organ in the United States, with more than 17,000 transplants performed each year. Following kidney transplant, patients are routinely placed on a regimen of immunosuppressant medications to prevent organ rejection, which often includes calcineurin inhibitors (CNIs) as the backbone medication of this regimen.

16 Mar 2016

Scientists synthesize novel selenohydantoins with anticancer and antioxidant activity

A group of scientists from Moscow universities led by Yan Ivanenkov, the head of Laboratory of Medical Chemistry and Bioinformatics in MIPT, has succeeded in synthesizing a set of novel selenohydantoins with anticancer and antioxidant activity.

16 Mar 2016

Pharmaceutical News

Trimeprazine improves β cell function, slows progression of diabetes

Cobimetinib with vemurafenib may have added benefit in melanoma with BRAF V600 mutation

Penn study calls on physicians to avoid over-prescribing opioids for surgical patients

Paracetamol does not meet minimum standard of clinical effectiveness in osteoarthritis patients

New meta-analysis supports link between intake of omega-3 fatty acids and reduction in MDD

Breckenridge Pharmaceutical announces final FDA approval for Gabapentin Oral Solution

EPFL scientists develop cutting-edge treatment for Alzheimer's disease

Older types of arthritis medicine appear to be dangerous for the heart

Researchers find major gap in treatment for AF patients at higher risk for stroke

WSU researcher explores new drugs to treat neurological disorders linked to autophagic dysfunction

Study finds disparities in discontinuing diabetes drug rosiglitazone following FDA safety alert

New study reveals why certain cancer drugs not always effective in halting tumor growth

Biomarkers may provide novel approaches to monitoring immunosuppressive therapy in organ transplant patients

Hedrin celebrates 10th anniversary with launch of new packaging

Johns Hopkins scientists develop antibody to curb lung tumor cell growth, breast cancer metastasis

Study: Statin drugs can reduce time to clear tuberculosis infection in mice

New treatment reduces cerebral damage in out-of-hospital cardiac arrest patients

Anti-anxiety drug reduces autistic features in Jacobsen syndrome mice

Many kidney transplant patients may benefit from lower-than-standard dose of CNIs

Scientists synthesize novel selenohydantoins with anticancer and antioxidant activity

PhD researcher at LifeArc

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