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New study reveals how GLP-1 receptor agonists enhance preingestive fullness

GLP-1 receptor agonists promote the feeling of fullness before eating via neurons in the dorsomedial hypothalamus, according to a new study. The findings offer new insights into the neural pathways by which GLP-1 receptor agonists increase the feeling of fullness to prevent overconsumption of food, which is key in mitigating obesity. Glucagon-like-peptide-1 (GLP-1) plays an important role in signaling the feeling of fullness after eating.

27 Jun 2024

PFDN6 protein could be a new target for colorectal cancer treatment

Researchers have identified a protein called PFDN6 that may play a role in the development and spread of colorectal cancer (CRC).

27 Jun 2024

CHARMs: A new hope for prion disease therapy

Drug development is typically slow: the pipeline from basic research discoveries that provide the basis for a new drug to clinical trials to production of a widely available medicine can take decades.

27 Jun 2024

Dietary fiber intake reshapes tryptophan metabolism, promoting gut health and reducing disease risks

A recent study in Nature Microbiology reveals that increased dietary fiber intake directs microbial tryptophan metabolism, leading to health benefits such as improved gut mucosa integrity and reduced risk of metabolic disorders.

27 Jun 2024

Rice and MD Anderson collaborative harnesses engineering expertise for cancer solutions

Led by Rice's Gang Bao and MD Anderson's Dr. Jeffrey Molldrem, the initiative aims to foster collaboration between the two institutions on fundamental and translational cancer research, to develop new technologies for cancer detection and therapy and to secure external funding in support of further research and training.

27 Jun 2024

Understanding the role of vaccination in mitigating long COVID brain fog

Since the outset of the COVID-19 pandemic, 10 to 30 per cent of the general population has experienced some form of virus-induced cognitive impairment, including trouble concentrating, brain fog or memory loss.

27 Jun 2024

The BII & Science Translational Medicine Prize launched for recognizing breakthroughs in women's health

In collaboration with the BioInnovation Institute (BII), AAAS is announcing the establishment of the BII & Science Translational Medicine Prize for Innovations in Women's Health.

27 Jun 2024

Targeted gene therapy may reduce AML burden and protect the heart from cardiotoxicity

Researchers from the University of Missouri School of Medicine found that a targeted gene therapy may make acute myeloid leukemia (AML) more sensitive to chemotherapy, while also protecting the heart against toxicity often caused by cancer treatments.

27 Jun 2024

Study identifies mechanism that impedes the effectiveness of melanoma therapies

In many cases of malignant melanoma, the effect of targeted treatment is lost over time. A research team from UZH and USZ has now discovered that a factor secreted by tumor cells is responsible for the resistance.

27 Jun 2024

Discovery of nanoparticle-based drug delivery system could revolutionize schizophrenia treatment

Schizophrenia is a complicated mental health disorder accompanied by wide range of symptoms such as hallucinations, impaired cognitive ability, and disorganized speech or behavior.

27 Jun 2024

Chronic loneliness associated with higher stroke risk independent of depressive symptoms or social isolation

Researchers determined the relationship between loneliness and incident stroke risk in the United States.

27 Jun 2024

AI breakthrough: Speech analysis predicts Alzheimer's progression with 78.5% accuracy

A method for predicting Alzheimer’s disease (AD) progression.

27 Jun 2024

Diabetes decoded: How your gut microbiome influences disease risk

How microbial features and functions specific to subspecies and strains contribute to the pathological mechanisms of type 2 diabetes.

27 Jun 2024

New-onset anxiety in adults aged 50+ doubles risk of developing Parkinson's disease

Researchers investigated Parkinson's disease (PD) risk among individuals with new-onset anxiety and associated risk factors.

27 Jun 2024

Study shows high rates of unrecognized heart valve disease in healthy seniors

The sheer scale of undiagnosed heart valve disease in our ageing population has been revealed for the first time, thanks to new research led by the University of East Anglia.

27 Jun 2024

Study identifies key neurons controlling threat response and escape in mice

Neuroscientists have discovered how the brain bidirectionally controls sensitivity to threats to initiate and complete escape behaviour in mice. These findings could help unlock new directions for discovering therapies for anxiety and post-traumatic stress disorder (PTSD).

27 Jun 2024

Cell division's hidden safety mechanism may influence cancer growth

Before a cell commits fully to the process of dividing itself into two new cells, it may ensure the appropriateness of its commitment by staying for many hours - sometimes more than a day - in a reversible intermediate state, according to a discovery by researchers at Weill Cornell Medicine. Their revelation of this fundamental feature of biology includes details of its mechanisms and dynamics, which may inform the development of future therapies targeting cancers and other diseases.

27 Jun 2024

Amorphous calcium phosphate drives aortic valve stiffening

The human body has sophisticated defenses against the deposition of calcium minerals that stiffen heart tissues, researchers at the University of Illinois Urbana-Champaign and collaborators at UCLA Health and the University of Texas at Austin found in a new study that provides the first detailed, step-by-step documentation of how calcification progresses.

27 Jun 2024

Researchers identify key players in abnormal bone differentiation

A study conducted by researchers at Baylor College of Medicine and collaborating institutions reveals the molecular events leading to osteogenesis imperfecta type V, a form of brittle bone disease caused by a mutation in the gene IFITM5.

27 Jun 2024

Early diagnosis key in combating the deadly effects of AL amyloidosis

AL (immunoglobulin light chain) amyloidosis is a rare disease that often results in progressive organ dysfunction, organ failure and eventual death.

27 Jun 2024

Medical Science News

New study reveals how GLP-1 receptor agonists enhance preingestive fullness

PFDN6 protein could be a new target for colorectal cancer treatment

CHARMs: A new hope for prion disease therapy

Dietary fiber intake reshapes tryptophan metabolism, promoting gut health and reducing disease risks

Rice and MD Anderson collaborative harnesses engineering expertise for cancer solutions

Understanding the role of vaccination in mitigating long COVID brain fog

The BII & Science Translational Medicine Prize launched for recognizing breakthroughs in women's health

Targeted gene therapy may reduce AML burden and protect the heart from cardiotoxicity

Study identifies mechanism that impedes the effectiveness of melanoma therapies

Discovery of nanoparticle-based drug delivery system could revolutionize schizophrenia treatment

Chronic loneliness associated with higher stroke risk independent of depressive symptoms or social isolation

AI breakthrough: Speech analysis predicts Alzheimer's progression with 78.5% accuracy

Diabetes decoded: How your gut microbiome influences disease risk

New-onset anxiety in adults aged 50+ doubles risk of developing Parkinson's disease

Study shows high rates of unrecognized heart valve disease in healthy seniors

Study identifies key neurons controlling threat response and escape in mice

Cell division's hidden safety mechanism may influence cancer growth

Amorphous calcium phosphate drives aortic valve stiffening

Researchers identify key players in abnormal bone differentiation

Early diagnosis key in combating the deadly effects of AL amyloidosis

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

How GLP‑1 Agonists Are Shaping the Future of Obesity Treatment With Dr Bryony Henderson

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