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New CAR T cells offer controlled treatment for solid tumors

Ludwig Cancer Research scientists have devised new types of chimeric antigen-receptor (CAR) T cells - a type of cancer immunotherapy - that can be switched on to varying degrees of intensity and then switched off on demand with existing drugs.

21 Oct 2024

Home-based brain stimulation shows promise in treating depression

A device that delivers direct stimulation to the brain was found to be a safe and effective means of treating depression at home, according to a new study by researchers at UTHealth Houston; the Institute of Psychiatry, Psychology & Neuroscience at King's College London; and the University of East London.

21 Oct 2024

New light-activated technology enhances immune cells' ability to target solid tumors

Immunotherapies that mobilize a patient's own immune system to fight cancer have become a treatment pillar. These therapies, including CAR T-cell therapy, have performed well in cancers like leukemias and lymphomas, but the results have been less promising in solid tumors.

21 Oct 2024

Cancer cells use ribosomes to evade immune detection, study shows

The protein factories of our cells are much more diverse than we thought they were. Scientists from the Netherlands Cancer Institute have now shown that cancer cells can use these so-called ribosomes to boost their invisibility cloak, helping them hide from the immune system.

21 Oct 2024

Earlier colorectal cancer screening can benefit younger adults

The updated national colorectal cancer screening guidelines that recommend screening begin at age 45 - rather than 50 - can benefit younger adults, a new Kaiser Permanente study found.

21 Oct 2024

New PET scan effectively detects benign insulinomas in the pancreas

A new PET scan reliably detects benign tumors in the pancreas, according to research led by Radboud university medical center.

21 Oct 2024

Methadone more effective than buprenorphine in reducing treatment discontinuation

People with opioid use disorder in British Columbia who received methadone had a 37–40 per cent lower rate of treatment discontinuation compared with those who received buprenorphine/naloxone.

21 Oct 2024

Major study links loneliness to increased risk of dementia

New research led by Florida State University College of Medicine faculty quantified the association between loneliness and dementia by analyzing data from more than 600,000 people around the world - the largest study of its kind.

21 Oct 2024

Novel antibodies show promise for tumor targeting and RAD51 inhibition

A new research paper was published in Oncotarget's Volume 15 on October 1, 2024, entitled, "Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition."

21 Oct 2024

Emory researchers discover enzyme to combat IgG-mediated disorders

Myasthenia gravis (MG) is a chronic autoimmune disorder in which antibodies block communication between nerves and muscle, resulting in weakness of the skeletal muscles.

21 Oct 2024

Study reveals complex role of polyploidy in cancer and treatment resistance

Polyploidy is a state where a cell contains more copies of the genetic material than the usual "diploid" cell, which contains two copies.

21 Oct 2024

New prediction model helps identify epilepsy risk after stroke

Researchers from 15 countries, led by Amsterdam UMC, have developed a way to predict which patients are at risk of epilepsy after a cerebral venous sinus thrombosis (CVT).

21 Oct 2024

Mental health problems lead to greater productivity loss than other chronic conditions

Depression and other mental health issues reduce the number of productivity-adjusted life years (PALYs) more than musculoskeletal diseases or cardiovascular diseases, according to a recent joint study by the University of Eastern Finland, the Finnish Social Insurance Institution (Kela), and Monash University in Australia.

21 Oct 2024

Long-term antiviral treatment may protect vision from shingles

Taking an antiviral medication for a year may prevent vision damage associated with shingles that affects the eye, according to new research led by faculty from the Perelman School of Medicine at the University of Pennsylvania and the NYU Grossman School of Medicine.

21 Oct 2024

Unraveling the mechanisms of B-cell maturation in blood cancer

Over four hundred people, 80% of them being children under 14 years old, will be diagnosed with B-cell Acute Lymphoblastic Leukaemia (B-ALL) next year in Spain, according to the latest projections from the Spanish network of cancer registries (REDECAN).

21 Oct 2024

New guidelines focus on preventing first strokes through healthy living

Healthy lifestyle behaviors, such as good nutrition, smoking cessation and being physically active, along with routine health screenings and managing risk factors for cardiovascular disease and stroke with medication, can help prevent individuals from having a first stroke.

21 Oct 2024