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New in vitro platform predicts drug toxicity, improving cancer treatment safety

Overcoming acquired treatment resistance is one of the major challenges in the fight against cancer. While combination therapies hold promise, their toxicity to healthy tissue remains a major hurdle. To anticipate these risks, researchers at the University of Geneva (UNIGE) have developed in vitro models of the kidneys, liver, and heart - three organs particularly sensitive to such therapies.

16 Dec 2025

Study reveals significant financial strain on families seeking mental healthcare

Behavioral health care has surged to represent 40 % of all medical expenditures for U.S. children in 2022, nearly doubling from 22 % in 2011, according to a new study published in JAMA Pediatrics. Researchers found that pediatric behavioral health expenditures totaled $41.8 billion in 2022, with families paying $2.9 billion out-of-pocket.

16 Dec 2025

Scientists discover rapid synapse adaptation in neuronal communication

Every movement you make and every memory you form depends on precise communication between neurons. When that communication is disrupted, the brain must rapidly rebalance its internal signaling to keep circuits functioning properly.

16 Dec 2025

Mediterranean diet and healthy habits improve cancer survival rates

Being more physically active, following a balanced diet, not smoking, and keeping body weight and blood pressure under control: the same habits that protect the heart also prove decisive after a cancer diagnosis.

16 Dec 2025

New research highlights the importance of social engagement for cognitive health

New research from the University of St Andrews has discovered a direct causal effect between social isolation and a faster decline in later- life cognitive function. Pathological cognitive decline is most often driven by Alzheimer's and related dementias.

16 Dec 2025

Scientists map how cinnamon’s bioactives interact with cancer signaling

This review synthesizes preclinical evidence showing that cinnamon-derived compounds can modulate inflammation, oxidative stress, apoptosis, and angiogenesis through multiple cancer-related signaling pathways. While biologically plausible, the findings are largely limited to cell and animal models, underscoring the need for pharmacokinetic, safety, and clinical validation.

15 Dec 2025

Indoor tanning loads normal skin with mutations linked to melanoma

Indoor tanning is associated with markedly higher mutation burdens and cancer-driving genetic changes in melanocytes taken from normal-appearing skin, including areas usually protected from sunlight. These molecular alterations provide a biological explanation for the higher odds of melanoma and multiple primary tumors seen in heavy tanning bed users.

15 Dec 2025

Circadian control of neutrophils limits heart damage after myocardial infarction

Neutrophils cause time-of-day–dependent collateral tissue damage after sterile injury through an intrinsic circadian program. Activating a CXCL12–CXCR4 checkpoint repositions neutrophils, limiting inflammatory injury without impairing antimicrobial defense.

15 Dec 2025

Gut bacteria patterns differ in autism and siblings and link to social symptoms

This sibling-controlled East Asian study found that autistic individuals, their unaffected siblings, and typically developing controls differ in gut microbiota diversity and composition, with the clearest separation between autism and typical development. Specific taxa, particularly the butyrate-producing genus Anaerostipes, were modestly associated with social communication and internalising symptoms, supporting a gut–behaviour link without implying causality.

15 Dec 2025

New initiative aims to transform care for early-onset cancer patients

More people under age 50 are developing cancer, and with that comes a shift in the model of care needed to serve this unique cancer patient population – including early access to fertility counseling, universal genomic testing to identify underlying genetic drivers, support resources to address long-term survivorship considerations, and community education regarding early detection and screening.

15 Dec 2025

GDF3 protein sustains harmful inflammation in aging immune cells

As people age, their bodies develop a dysfunctional immune system, which can leave older adults more susceptible to conditions like sepsis.

15 Dec 2025

AI uncovers hidden mechanisms of covert attention and emergent neuron types

Shifting focus on a visual scene without moving our eyes - think driving, or reading a room for the reaction to your joke - is a behavior known as covert attention.

15 Dec 2025

Chemotherapy may reduce HIV-infected T cells

Advancements in HIV/AIDS research, drug development and clinical practice since the 1980s have made it possible for people living with HIV to lead long, productive lives and keep the virus in check at undetectable levels and nontransmissible as long as therapy is maintained.

15 Dec 2025

Researchers explore how the visual brain system recovers following traumatic injury

The brain shows a capacity to recover from traumatic injury, which somewhat contradicts the widely accepted idea that neurons do not regenerate.

15 Dec 2025

Smartwatch alerts help parents manage children's tantrums

Mayo Clinic researchers have developed a smartwatch-based alert system that signals parents at the earliest signs of a tantrum in children with emotional and behavioral disorders - prompting them to intervene before it intensifies.

15 Dec 2025

Breast cancer disrupts stress hormone rhythms in the brain

"The brain is an exquisite sensor of what's going on in your body," says Cold Spring Harbor Laboratory Assistant Professor Jeremy Borniger. "But it requires balance. Neurons need to be active or inactive at the right times. If that rhythm goes out of sync even a little bit, it can change the function of the entire brain."

15 Dec 2025

Researchers uncover how Bartonella causes deadly Oroya fever

The so-called "Oroya fever" is an extremely severe infectious disease, yet it is classified among the so-called neglected tropical diseases.

15 Dec 2025

ADHD linked to higher risk of criminal convictions and family patterns

A largescale, comprehensive study has found that individuals with attention-deficit/hyperactivity disorder (ADHD) are at increased risk of being convicted of crimes compared to those without ADHD, and that this association extends to their relatives, suggesting shared familial factors such as genetics and environmental conditions.

15 Dec 2025

Air pollution and immune changes could trigger autoimmune conditions

A new study has linked air pollution exposure and immune-system changes that often precede the onset of autoimmune diseases.

15 Dec 2025

Advances in delivering oxygen-sensitive gut bacteria improve microbial therapies

Recent research has identified practical ways to protect and deliver oxygen-sensitive gut bacteria for a path toward safer, standardized microbial therapies that could reduce reliance on donor-based faecal microbiota transplants.

15 Dec 2025