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Cryo-EM reveals key atomic structures of the ends of actin filament

Actin filaments - protein structures critical to living movement from single cells to animals - have long been known to have polarity associated with their physical characteristics, with growing "barbed" and shrinking "pointed" ends.

8 Jun 2023

Insilico Medicine nominates pan-TEAD inhibitor as a potential solution for drug resistance in solid tumor patients

Insilico Medicine, a generative artificial intelligence (AI)-driven clinical-stage drug discovery company, today announced the nomination of ISM6331, a potential best-in-class pan-TEAD inhibitor, as a preclinical candidate compound (PCC) generated by Chemistry42, its proprietary generative chemistry-driven molecule design engine, targeting the Hippo pathway for the treatment of advanced solid tumors.

8 Jun 2023

Study uncovers novel mechanisms underlying plant immunity against major root disease

Researchers led by CHEN Yuhang and ZHOU Jianmin from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences have shown how plants resist clubroot, a major root disease that threatens the productivity of Brassica crops such as rape.

8 Jun 2023

Study shows how blood makes the brain’s immune cells toxic

In patients with neurological diseases like Alzheimer's disease and multiple sclerosis, immune cells in the brain known as microglia that normally fulfill beneficial functions become harmful to neurons, leading to cognitive dysfunction and motor impairment.

8 Jun 2023

Study provides a new perspective on the aberrant nature of B cell phenotypes in skin cancer

A new study that sheds light on how B cells react to skin cancer cells could pave the way for innovative therapy design.

8 Jun 2023

Penn Medicine researchers receive $6 million NIH grant to gain new insights on cardiac cellular identity

Historically, scientists have studied how cells develop and give rise to specialized cells, such as heart, liver, or skin cells, by examining specific proteins.

8 Jun 2023

Scientists identify the IL-17 protein as a determining factor in skin aging

A team of scientists from the Institute for Research in Biomedicine (IRB Barcelona) in collaboration with the National Center for Genomic Analysis (CNAG) has discovered that IL-17 protein plays a central role in skin aging.

8 Jun 2023

Study examines the combined toxicity of common environmental pollutants on the gut-brain axis

Regulating environmental pollution around the world still largely relies upon risk assessments of "single pollutants," ignoring combined toxicities and interactions of groups of substances.

8 Jun 2023

Teaming up with the patient’s immune system to combat cancer

The fact that our immune systems capture and destroy nanoparticles and the drugs they carry has been a problem in the field of nanomedicine for some time. But, in the fight against cancer, researchers are now attempting to exploit this problem to their advantage.

8 Jun 2023

SARS-CoV-2 virus can cause brain cells to fuse: Study

Researchers at The University of Queensland have discovered viruses such as SARS-CoV-2 can cause brain cells to fuse, initiating malfunctions that lead to chronic neurological symptoms.

8 Jun 2023

New process can help to design drugs with fewer or no side effects

Have you ever wondered how drugs reach their targets and achieve their function within our bodies? If a drug molecule or a ligand is a message, an inbox is typically a receptor in the cell membrane.

7 Jun 2023

Newborn genome sequencing project identifies unanticipated disease risks

Genomic sequencing of newborns reveals unanticipated genetic risks, prompting actionable medical interventions and potential life-saving care for infants and their families. This study highlights the value of comprehensive sequencing in newborns for early detection and management of genetic conditions.

7 Jun 2023

Middle-brain region linked to emotion control likely prompts females to kill their young

A middle-brain region tied to the control of emotions likely prompts females to kill their young, a new study in mice shows.

7 Jun 2023

Unlocking the complete potential of industrial hemp using genomics

Plant biologist Alex Harkess, PhD, and his lab at HudsonAlpha Institute for Biotechnology are on a mission to change the future of food and fiber crops, one flowering plant species at a time.

7 Jun 2023

DNAmFitAge: A new method to incorporate physical fitness into epigenetic clocks

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 10, entitled, "DNAmFitAge: biological age indicator incorporating physical fitness."

7 Jun 2023

Ancient, virus-like protein may contribute to ALS

More than 5,000 people are diagnosed annually with ALS (amyotrophic lateral sclerosis), a fatal, neurodegenerative disease that attacks nerve cells in the brain and spinal cord, gradually robbing people of the ability to speak, move, eat and breathe.

7 Jun 2023

Gene drive technology could help eradicate malaria

Population-level changes in the genetic make-up of one of the world's deadliest animals could provide a key in the fight against malaria, proponents of a radical new technology argue.

7 Jun 2023

New insights into how aggressive cancer cells proliferate and propagate the disease

Not all cancer metastases have the same destructive effect. Researchers demonstrate different mechanisms in experiments.

7 Jun 2023

Axol Bioscience collaborates with StrataStem to deliver stem cell based ‘clinical trial in a dish’ for Alzheimer’s disease

Axol Bioscience Ltd. (Axol), a leading pluripotent stem cell technology provider for drug discovery has signed an exclusive agreement with StrataStem to access and commercialize its extensive collection of Alzheimer’s Disease (AD) patient samples.

From Axol Bioscience Ltd 7 Jun 2023

Experts provide neural evidence for the glimpsing model of speech perception

Researchers led by Dr. Nima Mesgarani at Columbia University, US, report that the brain treats speech in a crowded room differently depending on how easy it is to hear, and whether we are focusing on it. Publishing June 6th in the open access journal PLOS Biology, the study uses a combination of neural recordings and computer modeling to show that when we follow speech that is being drowned out by louder voices, phonetic information is encoded differently than in the opposite situation. The findings could help improve hearing aids that work by isolating attended speech.

7 Jun 2023

Life Science News

Cryo-EM reveals key atomic structures of the ends of actin filament

Insilico Medicine nominates pan-TEAD inhibitor as a potential solution for drug resistance in solid tumor patients

Study uncovers novel mechanisms underlying plant immunity against major root disease

Study shows how blood makes the brain’s immune cells toxic

Study provides a new perspective on the aberrant nature of B cell phenotypes in skin cancer

Penn Medicine researchers receive $6 million NIH grant to gain new insights on cardiac cellular identity

Scientists identify the IL-17 protein as a determining factor in skin aging

Study examines the combined toxicity of common environmental pollutants on the gut-brain axis

Teaming up with the patient’s immune system to combat cancer

SARS-CoV-2 virus can cause brain cells to fuse: Study

New process can help to design drugs with fewer or no side effects

Newborn genome sequencing project identifies unanticipated disease risks

Middle-brain region linked to emotion control likely prompts females to kill their young

Unlocking the complete potential of industrial hemp using genomics

DNAmFitAge: A new method to incorporate physical fitness into epigenetic clocks

Ancient, virus-like protein may contribute to ALS

Gene drive technology could help eradicate malaria

New insights into how aggressive cancer cells proliferate and propagate the disease

Axol Bioscience collaborates with StrataStem to deliver stem cell based ‘clinical trial in a dish’ for Alzheimer’s disease

Experts provide neural evidence for the glimpsing model of speech perception

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

How GLP‑1 Agonists Are Shaping the Future of Obesity Treatment With Dr Bryony Henderson

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production

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