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Proton therapy dose escalation may improve outcomes for glioblastoma patients

Previously, results from the photon cohort of the NRG-BN001, a signal seeking Phase II randomized trial, indicated that photon radiation dose intensification (75 Gy) did not demonstrate improvement in overall survival (OS) for patients with newly diagnosed glioblastoma (GBM).

30 Sep 2025

Study shows prediabetes remission does not always require weight loss

Remission of prediabetes can occur even without weight loss, protecting against type 2 diabetes in up to 22% of individuals. Metabolic improvements, healthier fat distribution, and enhanced β-cell function, not body weight change, drive this benefit.

30 Sep 2025

Harnessing “DNA surgery” to develop therapeutic medicines for genetic liver and heart diseases

Genome editing is increasingly recognized as a leading frontier in biomedical research and an essential driver of healthcare innovation.

30 Sep 2025

Digital tools and chatbots can expand genetic counseling for young cancer survivors

A groundbreaking new study from the Alliance for Clinical Trials in Oncology aims to test whether digital tools and chatbot technology can help young adult cancer survivors get the genetic counseling they need to better understand future health risks to themselves and family members.

30 Sep 2025

Khat use linked to autoimmune hepatitis in young men

Khat (Catha edulis), a plant chewed for its stimulant effects by millions in East Africa and the Arabian Peninsula, is increasingly recognized for its hepatotoxic potential.

30 Sep 2025

Inflammation at the heart’s core: What clinicians and families can do now

Chronic low-grade inflammation is a key driver of cardiovascular disease, even when cholesterol is controlled. The ACC’s 2025 Scientific Statement highlights hsCRP as a routine risk marker and outlines lifestyle and pharmacologic anti-inflammatory strategies for prevention and treatment.

30 Sep 2025

Olive oil intake is linked to lower belly fat and healthier weight

Regular consumption of extra-virgin olive oil was associated with lower BMI and waist circumference in a study of more than 16,000 adults. EVOO also mediated over 60% of the Mediterranean diet’s impact on central obesity while showing an independent association with waist circumference.

30 Sep 2025

Cannabis extract eases chronic back pain and improves quality of life in major clinical trial

A phase 3 trial in Nature Medicine found that a full-spectrum Cannabis sativa extract (VER-01) significantly reduced chronic low back pain and improved sleep and function compared with placebo. The extract was safe, well-tolerated, and showed no signs of abuse or dependence, with benefits maintained over long-term treatment.

30 Sep 2025

Randomized trial shows exercise benefits for post-COVID immune regulation

Exercise can help to restore a more normal, well-regulated immune system in people with post-COVID syndrome, according to a gold-standard randomised-controlled trial presented at the European Respiratory Society Congress in Amsterdam, the Netherlands.

30 Sep 2025

Categorizing the risk factors for portal vein thrombosis in liver cirrhosis

Portal vein thrombosis (PVT) is a critical complication in liver cirrhosis (LC), significantly worsening portal hypertension and accelerating the progression to decompensation.

30 Sep 2025

Intranasal adrenaline can be as effective as the EpiPen

Instead of stabbing yourself, or someone else, in the thigh with a needle to deliver a dose of adrenaline to counter anaphylactic shock, would it not be easier to use a nasal spray instead?

30 Sep 2025

Undiagnosed G6PD deficiency can lead to delayed diabetes diagnosis for Black and Asian men

A common but often undiagnosed genetic condition may be causing delays in type 2 diabetes diagnoses and increasing the risk of serious complications for thousands of Black and South Asian men in the UK - and potentially millions worldwide.

30 Sep 2025

Stereotactic radiotherapy offers long-term survival outcomes comparable to surgery for NSCLC patients

A new clinical trial report finds that stereotactic radiation therapy offers long-term survival outcomes comparable to surgery for patients with small, early-stage non-small cell lung cancer (NSCLC). Patients in the study who received radiation also reported fewer side effects after treatment.

30 Sep 2025

New immune system assessment tool could help guide critical care treatment

When a patient enters the emergency department in critical condition, doctors must quickly run through a crucial list of questions: Does the patient have an infection? If so, is it bacterial or viral? Do they require treatment? Can the patient recover at home safely or do they need to be hospitalized?

30 Sep 2025

Discovery of EUDAL reveals new mechanism behind chemotherapy resistance in oral cancer

Oral cancer is one of the most common head and neck cancers worldwide, with hundreds of thousands of new cases diagnosed every year. Despite advances in surgery, radiotherapy, and chemotherapy, survival rates remain poor.

30 Sep 2025

Proton therapy offers no significant QOL advantage over photon therapy for breast cancer

The first randomized trial to compare photon- and proton-based radiation therapy for breast cancer finds that patients report equally strong health-related quality of life with either treatment. Patients who received proton therapy were more likely to say they would recommend or choose it again, but overall patient-reported outcomes were similar.

30 Sep 2025

Radiomics significantly outperforms clinical models for predicting NPC treatment outcome

Nasopharyngeal carcinoma (NPC) is a highly aggressive malignancy, with most patients presenting at locally advanced stages. While immune checkpoint inhibitors, such as PD-1 blockade, have reshaped treatment strategies, only a minority of patients achieve durable benefit. Accurate biomarkers for predicting treatment response remain an urgent unmet need.

30 Sep 2025

Tissue-mimicking hydrogels drive cell reprogramming via matrix remodeling

The mechanical properties of tissue matrix are crucial for maintaining cell health and function. With aging, tissue matrix loses its mechanical integrity and exhibits altered biophysical properties, which are closely associated with various diseases including neurodegenerative diseases and cancers.

30 Sep 2025

Myo-inositol fails to lower pregnancy risks in women with PCOS

Myo-inositol supplementation shows no significant benefits in preventing pregnancy complications for women with PCOS, according to a recent large-scale study.

30 Sep 2025

Researchers design factor IX variants for short- and long-term Hemophilia B management

After blood vessel damage, effective blood clotting is essential to halt bleeding. However, this process is inefficient in some individuals due to hereditary factors. Hemophilia B, for example, results from a deficiency in coagulation factor IX (FIX), which can lead to prolonged bleeding after injuries or surgery.

30 Sep 2025

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Medical Condition News

Proton therapy dose escalation may improve outcomes for glioblastoma patients

Study shows prediabetes remission does not always require weight loss

Harnessing “DNA surgery” to develop therapeutic medicines for genetic liver and heart diseases

Digital tools and chatbots can expand genetic counseling for young cancer survivors

Khat use linked to autoimmune hepatitis in young men

Inflammation at the heart’s core: What clinicians and families can do now

Olive oil intake is linked to lower belly fat and healthier weight

Cannabis extract eases chronic back pain and improves quality of life in major clinical trial

Randomized trial shows exercise benefits for post-COVID immune regulation

Categorizing the risk factors for portal vein thrombosis in liver cirrhosis

Intranasal adrenaline can be as effective as the EpiPen

Undiagnosed G6PD deficiency can lead to delayed diabetes diagnosis for Black and Asian men

Stereotactic radiotherapy offers long-term survival outcomes comparable to surgery for NSCLC patients

New immune system assessment tool could help guide critical care treatment

Discovery of EUDAL reveals new mechanism behind chemotherapy resistance in oral cancer

Proton therapy offers no significant QOL advantage over photon therapy for breast cancer

Radiomics significantly outperforms clinical models for predicting NPC treatment outcome

Tissue-mimicking hydrogels drive cell reprogramming via matrix remodeling

Myo-inositol fails to lower pregnancy risks in women with PCOS

Researchers design factor IX variants for short- and long-term Hemophilia B management

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

How GLP‑1 Agonists Are Shaping the Future of Obesity Treatment With Dr Bryony Henderson

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production

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